Thermo Fisher Scientific MED14 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
PIAPPGTPAVV LKSKMLFFLQ LTQKTSVPPQ EPVSIIVPII YDMASGTTQQ ADIPRQQNSS VAAPMMVSNI LKRFAEMNP

Highest antigen sequence identity to the following orthologs:

• Mouse: 100%
• Rat: 100%

Target Information

The activation of gene transcription is a multistep process triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus.
The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1.
It is also a component of other multisubunit complexes, such as thyroid hormone receptor-associated proteins, which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
This protein contains a bipartite nuclear localization signal and is known to escape chromosome X-inactivation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.