Thermo Fisher Scientific MRVI1 Polyclonal Antibody
Human MRVI1 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MRVI1. Recombinant protein control fragment (Product #RP-89975). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644213 |
Product Specific Information
Immunogen sequence:
NLVGLKLPDL SEAAEQEKGL PSELSPAIEE EESKSGLDVM PNISDVLLRK LRVHRSLPGS APPLTEKEVE NVFVQLSLAF RNDSYTLESR INQAERERNL
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 90%
Target Information
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, located in the endoplasmic reticulum membrane, is similar to Jaw1, a lymphoid-restricted protein downregulated during lymphoid differentiation.
Studies in mouse suggest MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, indicating this gene may function as a myeloid leukemia tumor suppressor.
Several alternatively spliced transcript variants encoding different isoforms have been found, some initiating translation at a non-AUG (CUG) start site.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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