Thermo Fisher Scientific Phospho-Rb (Ser780) Polyclonal Antibody
Rb 단백질의 Ser780 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA에 적합하며 Human, Mouse, Rat 반응성. 고순도 Affinity chromatography 정제 및 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around S780 of human RB (NP_0003122) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.42 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901824 |
Product Specific Information
- Positive Samples: NIH/3T3
- Immunogen sequence: TLSPI
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues. It forms complexes with SV40 large T antigen, adenovirus E1A, and HPV-16 E. Rb protein may regulate transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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