Thermo Fisher Scientific MEMO1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MEMO1 protein. Validated for ICC/IF applications with 0.25–2 µg/mL dilution. Purified via antigen affinity chromatography and supplied in PBS with glycerol. Suitable for research on cell migration and ERBB2 si...
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MEMO1. Recombinant protein control fragment (Product #RP-106802) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665222 |
Product Specific Information
Immunogen sequence:
MSNRVVCREAS HAGSWYTASG PQLNAQLEGW LSQVQSTKRP ARAIIAPHAG YTYCGSCAAH AYKQVDPSIT RRI
- Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 73%
Target Information
MEMO1 may control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. It acts as a mediator of ERBB2 signaling.
The MEMO1–RHOA–DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex.
It regulates the localization of APC and CLASP2 to the cell membrane via GSK3B activity.
Membrane-bound APC allows localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
MEMO1 is required for breast carcinoma cell migration.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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