Thermo Fisher Scientific GEMIN2 Monoclonal Antibody (OTI4A2), TrueMAB
인간 Gemin2(SIP1) 단백질을 표적으로 하는 마우스 단클론 항체로 Western blot에 적합. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 완충액에 보존. 연구용으로만 사용 가능.
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Applications
Tested Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A2 |
| Immunogen | Full length human recombinant protein of human SIP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with SMN and is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA showed abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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