Thermo Fisher Scientific CD38 Monoclonal Antibody (HIT2), Biotin

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-Dependent

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Miscellaneous PubMed (Misc)

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View 2 publications 2 publications

Product Specifications

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

HIT2

Immunogen

Human CD38

Conjugate

Biotin Biotin Biotin

View additional formats

• APC
• APC-Cyanine5.5
• FITC
• PE
• PE-Texas Red
• Qdot 655
• Request custom conjugation

Form

Liquid

Storage conditions

4° C, store in dark

Shipping conditions

Wet ice

Target Information

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter`s Syndrome.

Analyte Specific Reagent