Thermo Fisher Scientific IL-12RB1/CD212 Polyclonal Antibody
IL-12RB1/CD212 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. Mouse 및 Rat 시료에 반응하며 Protein A로 정제된 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse IL-12RB1 (amino acids 401–500) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The IL-12RB1/CD212 protein is a type I transmembrane receptor belonging to the hemopoietin receptor superfamily. It binds interleukin-12 (IL-12) with low affinity and forms part of the IL-12 receptor complex. The protein forms disulfide-linked oligomers essential for IL-12 binding activity. Coexpression with IL-12RB2 enables formation of high-affinity IL-12 binding sites and reconstitution of IL-12–dependent signaling. Deficiency of IL12RB1 expression can result in immunodeficiency with susceptibility to severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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