Thermo Fisher Scientific Cyclin T1 Polyclonal Antibody
Cyclin T1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로 HIV-1 Tat 단백질 관련 전사 활성 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 25 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the carboxy terminus of human CCNT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551859 |
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-34507 can be used with blocking peptide PEP-1550.
Target Information
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9 and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, multiple forms of p-TEFb may include one of several different cyclins along with cyclin-dependent kinase 9.
The complex containing this cyclin and its kinase partner acts as a cofactor of HIV-1 Tat protein, necessary and sufficient for full activation of viral transcription. This cyclin and CDK9 also trigger transcript elongation through phosphorylation of the carboxy-terminal domain of RNA polymerase II. Overexpression of this gene is implicated in tumor growth.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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