Thermo Fisher Scientific SAPAP3 Polyclonal Antibody
SAPAP3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. 인간 및 마우스 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며, 신경 시냅스 단백질 연구에 적합합니다.
- 카탈로그번호
- PA5100476
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DLGAP3 (Accession O95886), corresponding to amino acid residues P69–P119 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2849986 |
Product Specific Information
Antibody detects endogenous levels of total DLGAP3.
Target Information
SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is part of a protein family that interacts with PSD-95/SAP90, a membrane-associated guanylate kinase localized at the postsynaptic density (PSD) in neuronal cells.
SAPAP3 functions as an adaptor protein interacting with various synaptic scaffolding, cytoskeletal, and signaling proteins such as FAK and PYK2.
Both SAPAP3 protein and mRNA are localized to dendrites, while SAPAP1, -2, and -4 mRNAs are mainly found in cell bodies.
Studies suggest SAPAP3 may be involved in obsessive-compulsive disorder (OCD); mice lacking SAPAP3 show OCD-like behaviors that can be rescued by selective expression of SAPAP3 in the striatum.
At least two isoforms of SAPAP3 are known.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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