Thermo Fisher Scientific SLC1A6 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Immunocytochemistry (ICC/IF)

• Tested Concentration: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  KQFKTQYSTR VVTRTMVRTE NGSEPGASMP PPFSVENGTS FLENVTRALG TLQEMLSFEE TVPVPGS
• Highest antigen sequence identity:
  • Mouse: 85%
  • Rat: 82%

Target Information

SLC1A6 encodes a glutamate transporter, also known as excitatory amino acid transporter (EAAT4), belonging to the solute carrier family 6 (SLC1). EAATs are sodium- and potassium-dependent transporters widely distributed throughout the brain. SLC1A6 mediates uptake of L-glutamate, L-aspartate, and D-aspartate as a symporter, transporting amino acids together with Na⁺ and H⁺ ions, and counter-transporting K⁺ ions. It also mediates uncoupled Cl⁻ flux to prevent charge accumulation. SLC1A6 plays a crucial role in clearing glutamate from the synaptic cleft, terminating postsynaptic signaling. Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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