Thermo Fisher Scientific GCH1 Monoclonal Antibody (OTI3A3), TrueMAB
Thermo Fisher Scientific의 GCH1 Monoclonal Antibody (OTI3A3)은 인간, 마우스, 랫트 반응성을 가진 단클론 항체로 WB 및 IHC(P) 실험에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공되어 안정적인 저장이 가능합니다. 연구용으로만 사용됩니다.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A3 |
| Immunogen | Full length human recombinant protein of human GCH1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The GCH1 gene encodes a member of the GTP cyclohydrolase family. This enzyme catalyzes the conversion of GTP into 7,8-dihydroneopterin triphosphate, the first and rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis.
BH4 is an essential cofactor for aromatic amino acid hydroxylases and nitric oxide synthases.
Mutations in this gene are linked to malignant hyperphenylalaninemia and dopa-responsive dystonia. Several splice variants exist, not all of which produce functional enzymes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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