Thermo Fisher Scientific Phospho-CD247 (CD3 zeta) (Lys153) Monoclonal Antibody (EM-17), Alexa Fluor 488
Alexa Fluor 488으로 표지된 인산화 CD247 (CD3 zeta) 단일클론 항체로, T세포 내 Tyr153 인산화 부위를 특이적으로 인식합니다. Flow Cytometry에 적합하며, 인체 및 생쥐 반응성, 고순도 정제, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- MA538682
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Thermo Fisher Scientific Phospho-CD247 (CD3 zeta) (Lys153) Monoclonal Antibody (EM-17), Alexa Fluor 488
Applications
- Flow Cytometry (Flow): Tested Dilution 2–8 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-17 |
| Immunogen | A phospho specific peptide corresponding to the amino acids surrounding tyrosine 153 of mouse CD3 zeta linked to KLH |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898594 |
Additional Formats
- Unconjugated
- Alexa Fluor 647
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes phosphorylated intracellular tyrosine 153 of CD3 zeta chain (CD247), a component of the TCR/CD3 complex expressed on T cells.
Target Information
CD3z complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating TCR complex surface expression. The CD3 subunits (gamma, delta, epsilon, zeta) are immunoglobulin superfamily members encoded by genes on human chromosome 11. These subunits contain cytoplasmic tails with tyrosine-based motifs that mediate signaling molecule association. CD3 plays roles in TCR-induced growth arrest, cell survival, and proliferation. It is expressed on most T lymphocytes and thymocytes but not on B or NK cells. Altered expression may be observed in certain autoimmune diseases. Diseases associated with CD3z include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency due to CD3delta/CD3epsilon/CD3zeta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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