Thermo Fisher Scientific PILRA Polyclonal Antibody
Rabbit polyclonal antibody specific for Human PILR-alpha/PILRA protein. Validated for WB, ELISA, and IP applications. Preservative-free formulation; recommended sodium azide addition. Suitable for research use in cell signaling studies.
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- PA580901
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:25,000–1:50,000 |
| Immunoprecipitation (IP) | 1–2 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PILR-alpha/PILRA protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-specific |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2788165 |
Product Specific Information
- This product is preservative-free.
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
- This antibody has specificity for Human PILR-alpha/PILRA.
Target Information
SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR-alpha-mediated inhibition and PILR-beta-mediated activation.
These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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