Thermo Fisher Scientific XBP1 Monoclonal Antibody (9B7E5)
XBP1 단백질을 인식하는 마우스 모노클로날 항체로 Western blot 및 면역세포염색(ICC/IF)에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 인간, 마우스, 랫트 반응성. ER 스트레스 관련 XBP1 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9B7E5 |
| Immunogen | Recombinant protein corresponding to amino acids 2–160 of human XBP-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154615 |
Product Specific Information
A suggested positive control is XBP-1 recombinant protein.
Target Information
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.
Upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism mediated by the endonuclease IRE1. The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The unspliced isoform XBP1(U) is constitutively expressed and functions as a negative feedback regulator of XBP1(S), shutting off transcription of target genes during ER stress recovery.
A pseudogene of XBP1 has been identified and localized to chromosome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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