Thermo Fisher Scientific PI3R6 Polyclonal Antibody, Biotin

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 1:50–1:250

Product Specifications

Target Information

p87PIKAP (p87 PI3K adapter protein), also known as PIK3R6 (phosphoinositide-3-kinase, regulatory subunit 6), p84 or HsT41028, is a 754 amino acid cytoplasmic protein that functions as a regulatory subunit of the PI 3-kinase p110 complex.
Expressed in heart, dendritic cells, macrophages, and neutrophils, p87PIKAP drives PI 3-kinase p110 activation, interacts with PDE3B, and forms a scaffolding interaction.
The gene encoding p87PIKAP maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely p53 and BRCA1.
Tumor suppressor p53 maintains cellular genetic integrity through DNA repair and apoptosis regulation, while BRCA1 is a determinant of early-onset breast cancer and predisposition to ovarian, colon, prostate, and fallopian tube cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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