Thermo Fisher Scientific PI3R6 Polyclonal Antibody, Biotin
PIK3R6 단백질을 인식하는 Biotin 결합 Rabbit Polyclonal Antibody로, WB, ELISA, IP 등 다양한 응용에 사용 가능. 인간 및 생쥐 반응성, 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 -20°C 보관.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 590–640 on human PhosphoInositide 3-kinase regulatory subunit 6 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
p87PIKAP (p87 PI3K adapter protein), also known as PIK3R6 (phosphoinositide-3-kinase, regulatory subunit 6), p84 or HsT41028, is a 754 amino acid cytoplasmic protein that functions as a regulatory subunit of the PI 3-kinase p110 complex.
Expressed in heart, dendritic cells, macrophages, and neutrophils, p87PIKAP drives PI 3-kinase p110 activation, interacts with PDE3B, and forms a scaffolding interaction.
The gene encoding p87PIKAP maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely p53 and BRCA1.
Tumor suppressor p53 maintains cellular genetic integrity through DNA repair and apoptosis regulation, while BRCA1 is a determinant of early-onset breast cancer and predisposition to ovarian, colon, prostate, and fallopian tube cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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