Thermo Fisher Scientific TOPORS Monoclonal Antibody (6D2)
인간 TOPORS 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 ELISA에 적합합니다. E3 유비퀴틴 및 SUMO1 리가아제 기능 연구에 활용 가능하며, 암 억제 및 세포 성장 조절 관련 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D2 |
| Immunogen | TOPORS (NP_005793, 98 a.a. ~205 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SPDSKCPICL DRFDNVSYLD RCLHKFCFRC VQEWSKNKAE CPLCKQPFDS IFHSVRAEDD FKEYVLRPSY NGSFVTPDRR FRYRTTLTRE RNASVYSPSG PVNRRTTT
Target Information
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase.
Probable tumor suppressor involved in cell growth, cell proliferation, and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation.
May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins.
May be involved in DNA damage-induced cell death through IKBKE sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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