Thermo Fisher Scientific Phospho-DNA-PK (Ser2056) Polyclonal Antibody
DNA-PK의 Ser2056 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. Human 반응성, 항원 친화 크로마토그래피로 정제. 고농도 액상 형태로 제공되며 4°C 또는 -20°C 보관 권장.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-DNA-PK (Ser2056) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human DNA-PKcs (phospho Ser2056). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736366 |
Product Specific Information
- Positive Control: 293T, 293T (100 J/m² UVC treatment)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase, closely related to PI3 kinases, and often inhibited by small molecules targeting PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for the expression of nearly all genes. The complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting pre-initiation complex formation.
Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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