Thermo Fisher Scientific MED28 Monoclonal Antibody (OTI7H4), TrueMAB
인간 MED28 단백질을 인식하는 마우스 단클론 항체로 Western blot에 최적화됨. Affinity chromatography로 정제된 액상 제품이며, PBS/BSA/glycerol buffer에 보관. MED28 연구 및 전사 조절 관련 연구에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7H4 |
| Immunogen | Full length human recombinant protein of human MED28 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The mediator complex is a multi-protein transcriptional co-activator expressed ubiquitously in eukaryotes and required for RNA polymerase II transcription. MED28 (also known as Magicin) is one of the mediator subunits, expressed in various cell lines and tissues.
Down-regulation of MED28 in NIH3T3 cells induces genes related to smooth muscle cell differentiation, while overexpression represses SMC gene expression.
MED28 can form a ternary complex with Grb2 and Merlin (NF2 tumor suppressor protein), suggesting a role in tumor suppression.
It has also been identified as an HIV dependency factor (HDF), implying potential as a drug target in HIV research.
At least two isoforms of MED28 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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