Thermo Fisher Scientific TACC3 Monoclonal Antibody (OTI8B7), TrueMAB
Human TACC3 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot, IHC, ICC/IF, Flow Cytometry에 사용 가능. Affinity chromatography로 정제된 액상 형태이며, PBS/BSA/glycerol buffer에 보존. 연구용으로 세포 성장 및 분화 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8B7 |
| Immunogen | Full length human recombinant TACC3 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.62 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TACC1 is located on the 8p11 chromosomal region, amplified in approximately 15% of breast tumor samples. The short arm of chromosome 8 also contains FGFR1, whose expression is enhanced in most breast cancers. Members of the TACC family (TACC1, TACC2, TACC3) map closely to FGFR genes (FGFR1, FGFR2, FGFR3) on chromosomes 4, 8, and 10. Due to their phylogenetic relationship, TACC and FGFR are thought to play similar roles in cell growth and differentiation. TACC1 contains a conserved C-terminal region similar to Drosophila D-TACC, which is necessary for normal spindle function. Mammalian TACC proteins interact with centrosomes and microtubules similarly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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