Thermo Fisher Scientific CD79a Monoclonal Antibody (HM47), PerCP-Cyanine5.5, eBioscience
CD79a 단백질을 인식하는 HM47 단클론 항체로, PerCP-Cyanine5.5로 표지되어 있습니다. 인간 및 다양한 종의 B세포 표지에 적합하며, 유세포분석(Flow Cytometry)에 최적화되어 있습니다. 높은 특이성과 재현성을 제공하며, 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 5 µL (0.03 µg)/test
Reported for intracellular staining and flow cytometric analysis.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Bovine, Dog, Chicken, Chimpanzee, Horse, Guinea pig, Human, Mouse, Non-human primate, Pig, Rhesus monkey, Rat |
| Published Species | Ferret |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PerCP-Cyanine5.5, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HM47 |
| Conjugate | PerCP-Cyanine5.5 |
| Excitation / Emission Max | 489 / 679 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1724097 |
Additional Formats
Product Specific Information
The monoclonal antibody HM47 recognizes the cytoplasmic domain of CD79a (mb-1), a 47 kDa membrane glycoprotein that associates with CD79b to form the heterodimeric B cell receptor (BCR).
This receptor mediates B cell signaling, leading to activation, apoptosis, or anergy. CD79a is expressed from the earliest pre-B cell stage to plasma cells and serves as a reliable marker for B cells, including B cell neoplasms and some non-B cell malignancies such as AML.
- Epitope: Typically amino acids 208–222 in human CD79a
- Reactivity: Human, Mouse, Rat, Dog, Primate (Rhesus, Chimpanzee, Macaque, Baboon), Pig, Guinea pig, Horse, Cow, Chicken
- Applications Reported: Intracellular staining followed by flow cytometric analysis
- Applications Tested: Pre-titrated and tested for intracellular staining and flow cytometry of normal human peripheral blood cells
- Recommended Use: 5 µL (0.03 µg) per test in 100 µL final volume; suitable for 10⁵–10⁸ cells/test
- Excitation/Emission: 488 nm / 695 nm (Blue Laser)
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD79a forms a disulphide-linked heterodimer with CD79b (B29), functioning as part of the B lymphocyte antigen receptor complex. It appears from the pre-B cell stage and persists until the plasma cell stage, where it is found intracellularly.
CD79a is present in most acute leukemias of precursor B cell type, B cell lines, B cell lymphomas, and some myelomas, but absent in myeloid or T cell lines.
Diseases associated with CD79a include Agammaglobulinemia 3 and Agammaglobulinemia, Non-Bruton type.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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