Thermo Fisher Scientific ATRX Polyclonal Antibody
ATRX 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간 시료에 반응하며 IHC 및 파라핀 조직 염색에 적합. 항원 친화 크로마토그래피로 정제된 비결합형 액상 항체로, 안정적인 4°C 보관 가능.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 2442 and the C-terminus (residue 2492) of human alpha thalassemia/mental retardation syndrome X-linked |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Little brown bat.
Target Information
ATRX encodes a protein that contains an ATPase/helicase domain and belongs to the SWI/SNF family of chromatin remodeling proteins. Mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations can cause changes in DNA methylation patterns, linking chromatin remodeling, DNA methylation, and gene expression in development. The protein undergoes cell cycle-dependent phosphorylation, regulating nuclear matrix and chromatin association, and is involved in gene regulation and chromosomal segregation during mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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