Thermo Fisher Scientific TNNI2 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:2,000

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C, and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function.

In addition to muscle tissues, this protein is found in corneal epithelium and cartilage, where it inhibits angiogenesis to suppress tumor growth and metastasis, and in mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.