Thermo Fisher Scientific KIM-1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail. Its endogenous ligand is Tim-4. CD365 functions as a receptor or co-receptor for several viruses including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses, binding via phosphatidylserine on viral envelopes. Polymorphisms in the HAVCR1 gene (encoding CD365) are linked to infection susceptibility and disease severity. CD365 also participates in T-cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines. A soluble form of CD365 can be generated by metalloproteinase-mediated cleavage.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.