Thermo Fisher Scientific CLN3 Polyclonal Antibody
Thermo Fisher Scientific CLN3 Polyclonal Antibody는 인간 및 마우스에서 반응하며, Batten 병 연구에 적합한 고품질 항체입니다. Western blot에서 1:1000 희석으로 사용 가능하며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 보존되어 안정적입니다.
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Applications
- Western Blot (WB): Tested dilution 1:1000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 250–284 amino acids from the central region of human CLN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634836 |
Product Specific Information
Predicted to react with monkey based on sequence homology.
Target Information
CLN3 is a highly glycosylated, hydrophobic, 438-amino acid protein with six transmembrane domains. It localizes to the lysosomal membrane and plays a role in lysosomal function. CLN3 may act as a chaperone involved in the folding and unfolding of other proteins, particularly subunit C of the ATP synthase complex.
Mutations in the CLN3 gene cause Batten disease, a recessively inherited neurodegenerative disorder of childhood characterized by lysosomal accumulation of hydrophobic material, mainly ATP synthase subunit C. Batten disease is the most common form of neuronal ceroid lipofuscinoses (NCLs) and presents with progressive vision loss, seizures, and psychomotor disturbances.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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