Thermo Fisher Scientific CD202b (TIE2) Monoclonal Antibody (33.1), eBioscience
CD202b(TIE2) 단백질을 인식하는 Monoclonal Antibody(33.1)로 인간, 마우스, 토끼, 랫드, 돼지 등에 반응. Western blotting에 적합하며, 혈관형성과 조혈 관련 연구에 활용 가능. Affinity chromatography로 정제된 고순도 항체.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rabbit, Rat |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 33.1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10870984 |
| Purity | >90% (SDS-PAGE) |
| Aggregation | <10% (HPLC) |
| Filtration | 0.2 µm post-manufacturing filtered |
Product Specific Information
This 33.1 monoclonal antibody reacts with human, mouse, rabbit, rat, pig, and zebrafish CD202b (Tie-2), a member of the tyrosine kinase receptor family. CD202b is expressed on endothelial and a subset of hematopoietic cells, playing a role in angiogenesis and hematopoiesis during embryonic development.
In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage-, c-Kit+, Sca1+ cells. Long-term multilineage repopulating cells were detected in Tie-2+, Lineage-, c-Kit+, Sca1+ cells but not in Tie-2-, Lineage-, c-Kit+, Sca1+ cells.
Applications Reported: This antibody has been reported for use in western blotting.
Applications Tested: Tested by immunoblotting of reduced cell lysate from the bEND3 cell line at ≤5 µg/mL. Recommended to titrate for optimal performance.
Target Information
The TEK receptor tyrosine kinase (TIE2) is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial-smooth muscle cell communication in venous morphogenesis, and TEK defects are linked to inherited venous malformations.
The ligand angiopoietin-1 binds to TIE2 and mediates signaling pathways involved in embryonic vascular development. Immunoblotting has shown TIE2 expression increases with thyroid-stimulating hormone and cAMP-elevating agents. Hematopoietic stem cells (HSCs) expressing TIE2 are quiescent, antiapoptotic, and adhere to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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