Thermo Fisher Scientific NOX4 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액 내 1 mg/mL 농도로 제공. NOX4 단백질을 표적으로 하여 세포 신호전달 및 산화환원 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human NOX4 (amino acids 1–578) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719800 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase similar to that responsible for reactive oxygen species (ROS) generation in neutrophils is thought to act in the kidney as an oxygen sensor regulating erythropoietin synthesis.
NOX4 functions as a redox messenger in intracellular signaling pathways contributing to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells.
Research suggests that NOX4 links the insulin receptor to cellular ROS generation, enhancing insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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