Thermo Fisher Scientific PSMB7 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine

Target Information

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure composed of 4 rings of 28 non-identical subunits (2 rings of 7 alpha subunits and 2 rings of 7 beta subunits). Proteasomes are distributed throughout eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The immunoproteasome, a modified form, processes class I MHC peptides.
The PSMB7 gene encodes a member of the proteasome B-type (T1B) family, a 20S core beta subunit. Expression is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.