Thermo Fisher Scientific RYBP Polyclonal Antibody
RYBP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 보존되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human RYBP aa 1–200/228 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932506 |
Target Information
RYBP is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, which maintains the transcriptionally repressive state of many genes, including Hox genes, during development.
This complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lys-119, resulting in heritable chromatin changes.
RYBP is involved in X-chromosome inactivation in females, regulation of TP53 stability and transcriptional activity, and may influence apoptosis through ubiquitin-mediated proteasomal degradation of target proteins such as FANK1.
It may also act as a transcriptional repressor and contribute to tumor suppression in breast cancer by down-regulating SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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