Thermo Fisher Scientific QKI Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal QKI 항체로 Western blot, IHC(P), ICC/IF에 적합. 항원 친화 크로마토그래피로 정제된 액상 제품이며, PBS(glycerol 포함) 완충액에 보관. 단기 4°C, 장기 -20°C 저장 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human QKI. Recombinant protein control fragment (Product #RP-102294) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646184 |
Product Specific Information
Immunogen sequence:
RAEIKLKRAV EEVKKLLVPA AEGEDSLKKM QLMELAILNG TYRDANIKSP ALAFSLAATA QAAPRIITGP APVLPPAALR TPTPAGPTIM PLIRQIQTAV MPNGTPHPTA AIVPPGPEAG LIYTPYEYPY TLAPATSILE YPIEPSGVL
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles, and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin has been found to protect against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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