Thermo Fisher Scientific KIBRA Polyclonal Antibody
KIBRA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Hippo 신호 경로 연구에 적합하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human KIBRA, amino acids 351–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway, which plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It also acts as a transcriptional coactivator of ESR1, essential for DYNLL1-mediated ESR1 transactivation, and functions as a regulator of collagen-stimulated activation of the ERK/MAPK cascade.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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