Thermo Fisher Scientific Girdin Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Girdin. Recombinant protein control fragment (Product #RP-102807). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Girdin,uniProtId:Q3V6T2-1,ncbiNodeId:9606,antigenRange:1514-1587,antigenLength:1871,antigenImageFileName:PA5-58247_Girdin_Q3V6T2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58247_Girdin_Q3V6T2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642014

Product Specific Information

Immunogen sequence: VPDDISTGKR RKELGAMAFS TTAINFSTVN SSAGFRSKQL VNNKDTTSFE DISPQGVSDD SSTGSRVHAS RPAS

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Target Information

Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.