Thermo Fisher Scientific Human LXR-b, Ligand Binding Domain, GST Tag Recombinant Protein
Recombinant human LXR-β ligand binding domain (amino acids 243–461) with GST tag. Expressed in baculovirus system, purified and ligand-free, ideal for ligand binding and coregulator displacement assays. Supplied as liquid in proprietary buffer, stored ...
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Applications
- Ligand Binding Assay (LBA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Baculovirus |
| Amino Acid Sequence | 243–461 |
| Tag | GST-tag |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | Proprietary buffer |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
LXR-β (Liver X Receptor beta) ligand binding domain is a 57.6 kDa recombinant human protein (amino acids 243–461) expressed as a GST fusion protein in baculovirus-infected insect cells.
This protein was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
Protein Form: Recombinant, Ligand Binding Domain
Target Information
The liver X receptors (LXRA and LXRB) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation.
LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed.
Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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