Thermo Fisher Scientific Phospho-Calnexin (Ser583) Polyclonal Antibody
Calnexin 단백질의 Ser583 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합. 고순도 액상 형태로 제공되며 1 mg/mL 농도 유지. ER 내 단백질 접힘 연구 및 세포 내 단백질 품질 관리 기전 분석에 활용 가능.
- 카탈로그번호
- PA538264
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-Calnexin (Ser583) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Calnexin around the phosphorylation site of Ser583 (N-R-SP-P-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554865 |
Target Information
Calnexin, also known as IP90, p88, and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and assist in the proper folding and assembly of polypeptides into multisubunit proteins.
Calnexin associates with MHC class I heavy chains, partial complexes of the T cell receptor, and B cell membrane immunoglobulin, but not with completed receptor complexes.
It functions as a chaperone that retains incompletely or improperly folded proteins in the ER.
Soluble ER resident proteins typically have a KDEL sequence for retention, whereas integral membrane proteins like calnexin lack KDEL but have positively charged cytosolic residues ensuring ER localization.
Calnexin structure includes:
- ER luminal domain: 461 amino acids
- Transmembrane segment: 22 amino acids
- Cytoplasmic tail: 89 amino acids
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-38264_Calnexin_P27824-1_Rabbit.svg, PA5-38264_Calnexin_P27824-1_Rabbit_PDP.jpeg)
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