Thermo Fisher Scientific HLA-ABC (MHC I) Monoclonal Antibody (246-B8.E7)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1-2 µg/mL

-

Flow Cytometry (Flow)

1-2 µg/10^6 cells

-

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

246-B8.E7

Immunogen

Human peripheral blood leukocytes if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HLA-ABC,uniProtId:P04439-1,ncbiNodeId:9606,antigenRange:1-365,antigenLength:365,antigenImageFileName:3105-MSM1-P1ABX_HLA-ABC_P04439-1_House_mouse.svg,antigenImageFileNamePDP:3105-MSM1-P1ABX_HLA-ABC_P04439-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:HLA-ABC,uniProtId:P01889-1,ncbiNodeId:9606,antigenRange:1-362,antigenLength:362,antigenImageFileName:3105-MSM1-P1ABX_HLA-ABC_P01889-1_House_mouse.svg,antigenImageFileNamePDP:3105-MSM1-P1ABX_HLA-ABC_P01889-1_House_mouse_PDP.jpeg,sortOrder:2},{targetFamily:HLA-ABC,uniProtId:P10321-1,ncbiNodeId:9606,antigenRange:1-366,antigenLength:366,antigenImageFileName:3105-MSM1-P1ABX_HLA-ABC_P10321-1_House_mouse.svg,antigenImageFileNamePDP:3105-MSM1-P1ABX_HLA-ABC_P10321-1_House_mouse_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumor defense. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.