Thermo Fisher Scientific Phospho-BID (Ser61) Polyclonal Antibody
Phospho-BID (Ser61) 폴리클로날 항체로 BID 단백질의 Ser61 인산화 상태를 검출. Western blot에 적합하며, Rabbit IgG 호스트 기반. 세포 사멸 경로 연구용으로 사용. 액상 형태로 4°C 보관, 1년의 권장 보관 기간.
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Applications
Western Blot (WB)
- Tested Dilution: 1:250–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Surrounding serine 61 of BID (UniProt ID: P70444-1, antigen range: 61, antigen length: 195) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.50 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It belongs to the BCL-2 family of cell death regulators. BID mediates mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the COOH-terminal fragment translocates to mitochondria to trigger cytochrome c release.
BID usually exists in an inactive form in the cytosolic fraction and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. The cleaved C-terminal fragment (p15) is sufficient to induce cytochrome c release, leading to apoptosis. Thus, BID acts as a molecular link between caspase 8 activation and mitochondrial death machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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