Thermo Fisher Scientific E2F3 Polyclonal Antibody
인간 E2F3 단백질을 인식하는 Rabbit Polyclonal 항체로, 세포주기 관련 연구에 적합합니다. ICC/IF 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액 형태로 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human E2F3. Recombinant protein control fragment (Product #RP-107394). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791829 |
Product Specific Information
Immunogen sequence:
TNNQDHNGNI PKPASKDLAS TNSGHSDCSV SMGNLSPLAS PANLLQQTED QIPSNLEGPF VNLLPPLLQE DYLL
Target Information
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and the action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain several evolutionally conserved domains found in most members of the family:
- DNA binding domain
- Dimerization domain (interacts with DP transcription factors)
- Transactivation domain enriched in acidic amino acids
- Tumor suppressor protein association domain embedded within the transactivation domain
E2F3, along with E2F1 and E2F2, also possesses an additional cyclin binding domain and binds specifically to retinoblastoma protein (pRB) in a cell-cycle dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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