Thermo Fisher Scientific EFHD2 Polyclonal Antibody
EFHD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제, 액상 형태로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific EFHD2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human EFHD2 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735756 |
Product Specific Information
- Positive Control: H1299, HeLaS3, mouse brain, rat brain
- Predicted Reactivity: Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
EFHD2 (also known as Swiprosin-1 or SWS1) is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology.
EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold required for Syk-, SLP-65-, and PLC-gamma2-dependent B-cell receptor (BCR)-induced calcium flux.
EFHD2 may regulate BCR-induced immature and primary B-cell apoptosis and controls spontaneous apoptosis through regulation of BCL2L1 abundance.
Additionally, EFHD2 acts as a negative regulator of the canonical NF-kappa-B-activating branch.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-78575_EFHD2_Q96C19-1_Rabbit.svg, PA5-78575_EFHD2_Q96C19-1_Rabbit_PDP.jpeg)
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