Thermo Fisher Scientific DGKD Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
KRSRSGKFRL VTKFKKEKNN KNKEAHSSLG APVHLWGTEE VAAWLEHLSL

Sequence homology:
Dog: 79%
Guinea Pig: 93%
Human: 100%
Mouse: 92%
Rabbit: 86%
Rat: 100%

Target Information

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades.
DGK-alpha influences cell activation and secretion of lethal exosomes, controlling cell death.
DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle.
DGK-gamma encodes full-length and truncated transcripts expressed in various human tissues, with greatest expression in retina.
DGK-delta is most abundant in skeletal muscle.
DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol and is expressed predominantly in testis.
DGK-theta is most abundant in the cerebellum and hippocampus.
DGK-iota is present in brain and retina as a predominant transcript of more than 12 kb.
DGK-eta is closely related to DGK-delta.
DGK-zeta is most abundant in brain and muscle.
DGKs have structural motifs that play regulatory roles, forming the basis for dividing the DGKs into five subtypes.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.