Thermo Fisher Scientific APC11 Polyclonal Antibody
APC11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot과 Immunocytochemistry에 적합하며 Human, Mouse, Rat 시료에서 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, 세포주기 조절 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the center of human APC11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151998 |
Product Specific Information
- Suggested positive control: NIH-3T3 cell lysate
- PA5-20955 can be used with blocking peptide PEP-1069
Target Information
Together with the cullin protein ANAPC2, APC11 constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
The APC/C complex mediates ubiquitination and subsequent degradation of target proteins, primarily forming Lys-11-linked polyubiquitin chains and, to a lesser extent, Lys-48- and Lys-63-linked chains.
APC11 may recruit E2 ubiquitin-conjugating enzymes to the complex.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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