Thermo Fisher Scientific IL-17A Polyclonal Antibody, HRP
IL-17A 폴리클로날 항체로 HRP 결합형이며, Mouse와 Rat에 반응합니다. Western blot, IHC, ELISA 등 다양한 면역실험에 사용 가능합니다. 정제된 Rabbit IgG 항체로 높은 특이성과 안정성을 제공합니다. 연구용 전용 제품입니다.
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Thermo Fisher Scientific IL-17A Polyclonal Antibody, HRP
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,500 |
| ELISA | 1:10,000–1:50,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This purified antibody was prepared from whole rabbit serum produced by repeated immunizations with full-length recombinant rat IL17-A protein. |
| Conjugate | HRP |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Buffer | 0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl, 10 mg/mL BSA |
| Contains | 0.01% gentamicin sulfate |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at 4°C prior to restoration.
- For extended storage, aliquot contents and freeze at -20°C or below.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- This product is stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
In ELISA and other immunoreactive assays, this antibody recognizes both native and recombinant rat IL17-A in cell supernatants and certain body fluids.
A control of similarly diluted normal rabbit IgG is recommended.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer of 136 amino acids, belonging to the IL-17 family (IL-17A–F), signaling through the IL-17R/CDw217 receptor.
It enhances ICAM-1 expression in human fibroblasts and stimulates epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
IL-17A regulates NF-kappa B and MAPK activities, stimulates IL-6 and COX-2 expression, and promotes nitric oxide (NO) production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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