Thermo Fisher Scientific Calretinin Polyclonal Antibody (DC8)
Rabbit polyclonal antibody recognizing human Calretinin (DC8). Useful for differentiating mesotheliomas from adenocarcinomas. Validated for IHC and ICC/IF. Supplied in liquid form, purified, stored at 2–8°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Clone | DC8 |
| Immunogen | Recombinant human calretinin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 2–8°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2925239 |
Product Specific Information
Calretinin is a calcium-binding protein (~29 kDa) belonging to the EF-hand protein family, which includes S-100 proteins. This antibody aids in differentiating mesotheliomas from adenocarcinomas.
Positive tissue: Human normal pleura lining / malignant mesothelioma
Expected staining pattern: Cytoplasmic and nuclear
Target Information
Calretinin is encoded by the CALB2 gene on chromosome 16. It belongs to the troponin C superfamily with six EF-hand motifs that enable calcium binding. Calretinin functions in calcium signaling, buffering, and modulation of neuronal excitability. It is expressed in mesothelium, mast cells, neural cells, hair follicles, and fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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