Thermo Fisher Scientific Human ZEB2 Synthetic Peptide
인간 ZEB2 단백질의 C-말단 부근 18개 아미노산 서열로 구성된 합성 펩타이드입니다. 항체 PA5-20980과 함께 차단 실험용으로 사용됩니다. 정제된 액상 형태로 PBS 완충액에 보관되며, 연구용으로만 사용 가능합니다.
- 판매단위
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human ZEB2.
PEP-1094 can be used as a blocking peptide with polyclonal antibody PA5-20980.
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs. Similar to ZEB1, ZEB2 inhibits transcription of the E-cadherin gene and induces epithelial-mesenchymal transition (EMT), a process regulating cell migration during embryonic development and wound healing.
ZEB2 can protect cells from DNA damage-induced apoptosis, suggesting a role in tumor progression. It is often observed in the cytoplasm of various cancer tissues, indicating regulated localization in normal and tumor cells. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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