Thermo Fisher Scientific Human Calpain 6 Synthetic Peptide
인간 CAPN6 단백질의 C-말단 18개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 PA5-20592의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며, PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide를 포함. -20°C 보관.
- 카탈로그번호
- PEP0712
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human CAPN6.
PEP-0712 can be used as a blocking peptide with polyclonal antibody PA5-20592.
Target Information
Calpain-6, also known as calpamodulin or calpain-X, is an intracellular, calcium-dependent cysteine protease. Calpain-6 has a more tissue-specific expression in adults than calpain-1 and calpain-2, and is primarily found in the placenta, though it is also expressed embryonically in several tissues.
The classical calpain family members consist of a common small subunit (calpain-4) and a large variable subunit, but it is not known if calpain-6 associates with a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain T in calpains 5 and 6).
Located on the X chromosome, the calpain-6 sequence lacks the EF-hand calcium-binding motif found in domain-IV of classical calpains. Additionally, the canonical active site residues Cys, His, and Asn are modified to Lys, His, Asn in human and Lys, Tyr, Asn in mouse calpain-6, making it unlikely that calpain-6 is proteolytically active.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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