Thermo Fisher Scientific PD-L1 Monoclonal Antibody (OTI4D4), TrueMAB
PD-L1 단백질을 인식하는 마우스 단클론 항체로, WB·ELISA·Luminex 분석에 사용 가능. 인간 PD-L1(CD274)에 특이적이며, carrier-free 형태로 제공되어 결합 실험에 적합. 연구용으로 면역회피 메커니즘 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:4,000 | |
| ELISA | Assay-dependent | |
| Luminex | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D4 |
| Immunogen | Full length human recombinant protein of human CD274 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family and binds specifically to the programmed death receptor 1 (PD-1). This interaction negatively regulates T-cell receptor (TCR) signaling, reducing TCR-mediated proliferation and cytokine production. PD-L1 is abundantly expressed on various murine and human cancers and can be upregulated by IFN-gamma stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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