Thermo Fisher Scientific BCL2L15 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: Raji
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, such as Bax, contain three of the four Bcl-2 homology regions (BH1–3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, a novel member of the Bcl-2 family containing BH2 and BH3 regions but lacking BH1 and BH4. Bfk is closely related to Bcl-G(L), lacks a C-terminal membrane anchor, and is cytosolic. Overexpression of Bfk weakly promotes apoptosis and antagonizes Bcl-2’s prosurvival function. Bfk does not bind other Bcl-2 family members, though its BH3 motif can mediate association with prosurvival proteins. Low levels of Bfk are found in stomach, ovary, bone marrow, and spleen, with increased expression in mammary gland during pregnancy, suggesting a role in mammary development.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.

제품 이미지

(이미지 파일: PA5-22139_BCL2L15_Q5TBC7-1_Rabbit.svg, PA5-22139_BCL2L15_Q5TBC7-1_Rabbit_PDP.jpeg)