Thermo Fisher Scientific VACWR117 Polyclonal Antibody

Thermo Fisher Scientific VACWR117 Polyclonal Antibody

Applications

• Western Blot (WB): Assay-dependent
• ELISA: Assay-dependent

Product Specifications

Target Information

Regulatory subunit of the mRNA cap enzyme which stabilizes the catalytic subunit and enhances its methyltransferase activity through an allosteric mechanism. The heterodimeric mRNA capping enzyme catalyzes the linkage of an N7-methyl-guanosine moiety to the first transcribed nucleotide (cap 0 structure), while the methyltransferase OPG102 is responsible for a second methylation at the 2′-O position of the ribose (cap 1 structure).
Also involved in early viral gene transcription termination and intermediate viral gene transcription initiation. Early gene transcription termination requires the termination factor VTF, the DNA-dependent ATPase NPH-I/OPG123, and the RAP94/OPG109 subunit of the viral RNA polymerase, as well as the presence of a specific termination motif.
Binds, together with RAP94/OPG109, to the termination motif 5′-UUUUUNU-3′ in the nascent early mRNA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.