Thermo Fisher Scientific NCOA4 Polyclonal Antibody
NCOA4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, PBS + 50% glycerol 저장. -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NCOA4 (Accession Q13772), corresponding to amino acid residues I499–L549 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900261 |
Product Specific Information
Antibody detects endogenous levels of total NCOA4.
Target Information
Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG, and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor.
In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo.
ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion.
ARA70a is widely expressed, with highest expression in testis and adipose tissues, whereas ARA70b is solely expressed in the testis.
ARA70a can function as a ligand-enhanced co-activator of PPARγ in adipocytes.
ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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