Thermo Fisher Scientific CD28 Monoclonal Antibody (37.51.1)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.25-0.5 µg / 1x10^6 cells

-

Neutralization (Neu)

-

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

-

View 9 publications 9 publications

Product Specifications

Published species

Mouse

Host/Isotype

Syrian hamster / IgG

Class

Monoclonal

Type

Antibody

Clone

37.51.1

Immunogen

Mouse T lymphoma EL-4 cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_2536584

Target Information

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary`s Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.