Thermo Fisher Scientific TCF12 Monoclonal Antibody (OTI2E11)
TCF12 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot과 IHC(Paraffin) 분석에 적합. 인간 시료 반응성 확인됨. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보존. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E11 |
| Immunogen | Full length human recombinant protein of TCF12 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725488 |
Target Information
TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG.
It is expressed in many tissues, including skeletal muscle, thymus, B- and T-cells, and may regulate lineage-specific gene expression through heterodimer formation with other bHLH E-proteins.
TCF12, in combination with E2A, is required to block thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation.
Recent studies indicate that TCF12 is also essential for invariant natural killer T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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