Thermo Fisher Scientific MDM2 Monoclonal Antibody (OTI22G3), TrueMAB
Human MDM2 단백질(aa 119-438)에 특이적인 Mouse IgG2b 단일클론 항체. Western blot에 1:2,000 희석으로 검증됨. 액상 형태, Affinity chromatography로 정제됨. PBS/BSA/glycerol buffer에 보관, -20°C에서 안정적.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI22G3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 119–438 of human MDM2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MDM2 is a ubiquitin ligase for p53 and plays a central role in regulating p53 stability. Located on chromosome 12q, MDM2 phosphorylation by Akt at Ser166 and Ser186 enhances its interaction with p300, promoting ubiquitination and degradation of p53. Phosphorylation also prevents binding to p19ARF, further increasing p53 degradation. Overexpression of MDM2 inhibits p53 transactivation and tumor suppressor function by promoting its degradation via E3 ubiquitin ligase activity. MDM2 is implicated in apoptosis and cell cycle regulation and is overexpressed in various human cancers including soft tissue carcinomas and breast cancer. It also interacts with proteins such as retinoblastoma 1 and ribosomal protein L5. Over 40 alternatively spliced transcript variants have been identified in both tumor and normal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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